At the top of NASA's list of core values is safety.
If safety were the only core value, they could achieve it best by staying out of space. Space is inherently dangerous. But their purpose is to explore space. None of their missions are risk-free. Safety is what they try to achieve in the context of danger.
Taking Artemis 2 astronauts through space in a small life-sustaining room is the task of their spacecraft, Orion.
What's outside? Just the harshest environment humans have ever faced: "extreme radiation, massive temperature swings, and deep space vacuum."

